We conducted the power analysis to demonstrate the power regarding the findings of null associations. We had sufficient power (80%) to detect an association with an OR of 1.50 for comorbid disorder with 30% prevalence such as panic attacks (Figure 1). For comorbid disorders with 20% prevalence such as major depressive disorder and social phobia, our sample had sufficient power (80%) to detect an association with an OR of 1.55. As the prevalence of comorbid disorders decreased to 10% as with alcohol dependence, cannabis dependence, PTSD, ADHD, conduct disorder, and ASPD, our sample had power (80%) to detect the association with an OR of 1.75. Therefore, we had power to detect only strong associations between the diplotypes and the comorbid disorders. In light of this limited power, we found no evidence of associations between the diplotypes and comorbid disorders and thus no evidence for pleiotropy.
