Table 4 shows the associations between the risk diplotype (rs16969968, rs588765) and each of the comorbid disorders to test the potential pleiotropic effect of these variants for nicotine dependence and the comorbid psychiatric disorders. We examined the risk for each comorbid disorder with age, gender, education, and diplotype in Model 1, and tested the potential mediating effect of nicotine dependence in Model 2. We found no evidence of associations between the diplotypes and any comorbid disorders. Although there were trends of association, none of the genetic associations were significant when adjusted for multiple comparisons. We found similar results when defining PTSD by excluding subjects without prior exposure to traumatic events.
