paperKB
coga / coga-kb
Help
Sign in

Chunk #87 — 6. Comparisons of the selectively bred rat lines — 6.1. Neurobehavioral differences

Source
Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.
Embedded
yes

Text

In a recent study (Roman et al., 2012), the Multiple Concentric Square Field (MCSF), Open Field (OF) and Elevated Plus Maze (EPM) tests were used to examine a number of anxiety-, impulsivity- and risk taking-like behaviors between the AA vs. ANA, HAD1 vs. LAD1, HAD2 vs. LAD2, P vs. NP as well as sP vs. sNP rat lines. The use of multiple behavioral measures, especially within one test session/apparatus, has been proposed to increase the reliability and comprehensiveness of the constructs measured (c.f., Meyerson et al., 2006; Ramos, 2008), which supports the utility and complexity (71 behavioral parameters were recorded) of the Roman and colleagues study (2012). In summary, the authors (Roman et al., 2012) noted that the sP line showed greater anxiety-related behaviors than the sNP line and the AA, and to a lesser extent the P, line(s) displayed higher risk-taking behavior than their low alcohol-consuming counterparts. These authors reported that the HAD1 and HAD2 lines could not be differentiated from the LAD1 and LAD2 lines on these two behavioral dimensions. This study (Roman et al., 2012) also revealed