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Chunk #88 — 6. Comparisons of the selectively bred rat lines — 6.1. Neurobehavioral differences

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Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.
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higher risk-taking behavior than their low alcohol-consuming counterparts. These authors reported that the HAD1 and HAD2 lines could not be differentiated from the LAD1 and LAD2 lines on these two behavioral dimensions. This study (Roman et al., 2012) also revealed that no single parameter within the MCSF, OF and EPM tests revealed a significant difference between high and low alcohol-consuming rats across all five line-pairs. In fact, only three (4%) of the parameters differentiated high from low alcohol-consuming rats across four of the line-pairs and 28 (41%) of the parameters differentiated high vs. low alcohol-consuming rats for only one line-pair. In addition, these tests were most sensitive in measuring differences within the sP vs. sNP and AA vs. ANA line-pairs and were relatively insensitive in detecting differences within the P vs. NP line-pair.