Of these 22 regions (Table 3), five regions have been reported previously as meeting genome-wide significance for schizophrenia (MHC, C10orf26, DPYD-MIR137, SDCCAG8, and MMP16) and two for schizophrenia, bipolar disorder, and a combined phenotype (CACNA1C and ITIH3-ITIH4). 14-17,27-29 For the remaining 15 regions, we now find genome-wide significance for a locus previously implicated only for bipolar disorder (NCAN)30 along with 14 novel regions.
