We highlight four themes from these results (see also Supplemental Table 9). First, these results implicate calcium signaling in the etiology of schizophrenia. As in prior studies of bipolar disorder and schizophrenia, 17,27,28 we found genome-wide significant support for CACNA1C (Cav1.2, P=5.2×10−12 at the intronic SNP rs1006737). Intriguingly, we identified a novel genome-wide significant association for CACNB2 (P=1.3×10−10 at the intronic SNP rs17691888) which encodes the β2 subunit of L-type calcium channels (Cav β2). A gene-set test supported the involvement of calcium channel subunits in the etiology of schizophrenia (Supplemental Table 7).
