Five SNPs in or adjacent to the genes SF3B4/SV2A, SOCS2, C17orf67, CABLES1 and DOT1L were associated at p<0.05 significance level with PHV2 (Table 2). Of these, three (related to SF3B4/SV2A, SOCS2 and C17orf67) associated with adult height in our sample. All five associated in the same direction as with adult height in the previous studies and in our study. Two of the five (related to SOCS2, CABLES1) and two additional SNPs (related to CDK6, C6orf106) associated with timing of pubertal growth spurt (ATO and/or age at PVH2) at p<0.05. However, as we did not have a similar prior evidence for association with the timing of height growth spurt as for height velocities, we cannot declare even the strongest association with age at PHV2 (C6orf106, p = 0.0057) statistically significant after a Bonferroni correction for multiple testing.
