Only SNP rs11205277 upstream of SF3B4/SV2A showed significant evidence for an association with both PHV1 and PHV2. SNP rs6830062 in LCORL had a similar effect size on PHV1 (beta 0.74%, 95% CI 0.19 to 1.21%) and PHV2 (0.88%, −0.44 to 2.17%) as had SNP rs6842303 in the same gene (PHV1 beta 0.38%, 0.01 to 0.76%, PHV2 beta 0.30%, −0.58 to 1.19%). The associations in LCORL were statistically significant for PHV1, but not PHV2, which may reflect inadequate power to detect association with PHV2.
