In the analytic sample, individuals with increased parietal-occipital theta EEG coherences had an increased number of maxdrinks (B: 2.03, p=0.03) and individuals with increased parietal-frontal low theta EEG coherence had a decreased number of maxdrinks (Beta= 2.11, p=0.03) and were less likely to meet criteria for DSM-5 AUD (B: 3.52, p<0.001). All six variants associated with parieto-occipital low theta (3-5 Hz) EEG coherence showed nominal positive associations with maxdrinks and DSM-5 AUD symptom count in both EA and AA COGA samples (Table 2) and with alcohol drinker status and alcohol intake frequency in the UK Biobank (Table 3). [Note, this excludes rs8088204 which was not assessed in the UK Biobank.] Given the high LD observed among these six SNPs, p-values were adjusted for the number of tests (1.2 for EAs and 2.1 for AAs) as estimated using the pnorm procedure53 and four alcohol phenotypes examined. Associations of rs12965943 and rs8088204 survived multiple test-correction (0.05/# of independent tests x four phenotypes= 0.021 for EAs and 0.012 for AAs) for both maxdrinks and DSM-5 AUD symptom count, and only among AA participants.
