and four alcohol phenotypes examined. Associations of rs12965943 and rs8088204 survived multiple test-correction (0.05/# of independent tests x four phenotypes= 0.021 for EAs and 0.012 for AAs) for both maxdrinks and DSM-5 AUD symptom count, and only among AA participants. Associations of rs12957925 and rs12457297 with maxdrinks among AA participants also survived a multiple test correction. All six SNPs were significantly (i.e., p<0.0001) associated with alcohol drinker status and alcohol intake frequency in the UK Biobank (Table 3), and withstood a multiple test correction; the minor allele was associated with increased AUD risk. None of the SNPs were significantly associated with DSM-IV AD in the PGC (Table 3).
