In a second linkage analysis, alcohol diagnoses were derived from the SSAGA using the DSM-IV criteria with the exception of the criterion requiring the temporal overlap or clustering of symptoms to provide a broader alcohol misuse phenotype as suggested by previous studies (Reich et al., 1998; Saccone et al., 2000; Wilhelmsen et al., 2003). Four additional linkage peaks were identified in this analysis. The strongest peak was identified at chromosome 2p24.3-p24.1. This region has been implicated in alcohol misuse phenotypes in a previous study (Wilhelmsen et al., 2005), and two additional studies identified a region approximately 60 cM centromeric of the current locus (Foroud et al., 2000; Reich et al., 1998). Further, previous linkage studies have suggested this region is involved in aspects of antisocial behavior (Ehlers et al., 2008; Kendler et al., 2006) and reward dependence (Cloninger et al., 1998), which are thought to influence drinking behavior. The three additional loci identified in the present study, 1p22.3 (Corbett et al., 2005; Foroud et al., 2000; Guerrini et al., 2005; Hill et al., 2004; Kuo et al., 2006; Reich et
