those subjects that are heterozygous for it to show unequal allelic expression (since homozygotes for rs1344706 would carry two functionally equivalent eQTL alleles). Our observed data were not compatible with this, there being no difference in the degree of differential expression in rs1344706 homozygotes compared with heterozygotes (t-test P=0.84, figure 3). This suggests that while rs1344706 is associated with expression, it is not responsible for it, or at least that it is not the only cis-acting eQTL. Similarly, analyses of the most strongly associated eQTLs from GeneVar revealed they are also associated with expression, but the comparison of homozygotes and heterozygotes for each putative eQTL suggest none are likely the causal eQTLs (supplemental figure 1).
