Following our original GWAS (4), association between schizophrenia and rs1344706, which lies in intron 2 of ZNF804A, has been independently replicated in three studies(5,10,11). Since our study was based upon fewer than 5% of all common SNPs in the genome, we assumed that rs1344706 was unlikely to be the susceptibility variant. Thus, we undertook a fine-mapping study, the aim of which was to identify the variant that was directly responsible for association. In spite of extensive investigation, we were unable to detect a more strongly associated variant. However, meta-analysis based upon ~60,000 subjects provided very strong evidence for association between rs1344706 and schizophrenia (P=2.54×10−11) and also a combined schizophrenia bipolar phenotype (P=4.1×10−13).
