Figures 3b and 3c show the results for the depressive symptoms and neuroticism lead-SNPs, respectively. In each panel, the blue crosses depict results from the quasi-replications where subjective well-being is the second-stage phenotype. We find that the two depressive symptoms lead-SNPs have the predicted sign for subjective well-being, and one is nominally significant (p = 0.04). Finally, of the eleven neuroticism lead-SNPs, nine have the predicted sign for subjective well-being. Four of the eleven are nominally significantly associated with subjective well-being, all with the predicted sign. One of the four is the SNP tagging the inversion on chromosome 816. That SNP’s association with neuroticism (and likely with subjective well-being) is driven by its correlation with the inversion (Supplementary Fig. 2).
