Results of the quasi-replication of the three subjective well-being lead-SNPs are shown in Figure 3a. For ease of interpretation, the reference allele for each association in the figure is chosen such that the predicted sign of the second-stage estimate is positive. We find that two out of the three subjective well-being lead-SNPs are significantly associated with depressive symptoms (p = 0.004 and p = 0.001) in the predicted direction. For neuroticism, where the second-stage sample size (N = 68,201) is about half as large, the subjective well-being-increasing allele has the predicted sign for all three SNPs, but none reach significance.
