To further probe the credibility of the findings, we performed “quasi-replication” exercises (Online Methods) in which we tested the subjective well-being lead-SNPs for association with depressive symptoms and neuroticism. We similarly tested the depressive symptoms lead-SNPs and the neuroticism lead-SNPs for association with subjective well-being. Below, we refer to the phenotype for which the lead SNP was identified as the first-stage phenotype and the phenotype used for the quasi-replication as the second-stage phenotype. To avoid sample overlap, for each quasi-replication analysis we omitted any cohorts that contributed to the GWAS of the first-stage phenotype.
