Table 2 summarizes 23 pleiotropic loci associated with at least four of the disorders. Among these loci, heterogeneity of effect sizes was minimal (p-value of Q > 0.1). Eleven of the 23 lead SNPs map to the intron of a protein-coding gene, and seven additional lead SNPs had at least one protein-coding gene within 100 kb. We used an array of functional genomics resources, including brain eQTL and Hi-C data (Wang et al., 2018; Won et al., 2016) to prioritize potential candidate genes to the identified regions (Online Methods; Fig. 2b). The Manhattan plot in Fig. 2c highlights some of the prioritized candidate genes.
