with more than one disorder). As expected, configurations of disease association reflected the differences in the statistical power and genetic correlations between the samples (Fig. S1). Of the 109 pleiotropic loci, 83% and 72% involved SCZ and BIP, respectively. MD, which had the largest case-control sample, was associated with 48% of the pleiotropic loci (N=52/109). Despite the relatively small sample size, ASD was implicated in 36% of the pleiotropic loci. Most of the ASD associations co-occurred with SCZ and BIP. The other disorders, ADHD, TS, OCD, and AN featured associations in 16%, 14%, 11%, and 7% of the pleiotropic loci, respectively. Of the single-disorder-specific loci, 81% and 16% were associated with SCZ and MD, respectively.
