One notable inclusion amongst the variants with more modest association signals is a cluster of SNPs on chromosome 10 including rs10748582 and rs7923866, which generate trend test P values between 10-4 and 10-5. This cluster maps in the vicinity of the HHEX (homeobox, hematopoietically expressed) and IDE (insulin-degrading enzyme) genes, in a region recently highlighted in a GWA scan for T2D performed in 1363 subjects of French origin109. The SNPs showing association in our data are proxies for those reported in the French study and generate similar effect-size estimates for T2D.
