their functional effects. Another reason explaining why elucidating disease mechanisms in neuropsychiatric disorders has remained challenging is that over 90% of identified variants are located within non-coding regions of the genome, indicating that regulatory elements—e.g., promoters, enhancers, and insulators—may explain part of the underlying genetic mechanisms in some polygenic disorders [4, 7]. Due to extensive linkage disequilibrium (LD), it is also challenging to identify a causal variant within a given associated locus [4].
