Considering the results of our gene–gene/protein–protein interaction’s investigation, we constructed three interaction networks, one each for AD, ND and OD. Supplementary Figure 1 shows the AD interaction network. We observed only ADH1B and ADH1C interacting between themselves and with other common interacting partners. The other AD GWAS-relevant genes were related only to specific interacting partners (i.e., CTBP2, HTR1A, GSS, KCNB2) or were not related to any interacting partners (i.e., THSD7B, SERINC2, NALCN, PKNOX2, DSCAML1, METAP1, KIAA0040, C15orf53, PDLIM5). In the ND interaction network, we observed that CHRNA3 and CHRNA5 have common interacting proteins. Conversely, CHRNB3 and ARHGAP10 did not interact (Supplementary Figure 2). In the OD interaction network, NCK2 and KCNG2 showed many interacting partners, having common interactions with PARVA and KCNC1, respectively (Supplementary Figure 3). In the OD interaction analysis, we saw no interactions for the APBB2 gene.
