The ΔF analysis of common variants (n = 51,079) indicated that allelic differences are greater in subjects of African ancestry (99.9th percentile of African ΔF = 0.690) than in those of Asian (99.9th percentile of Asian ΔF = 0.627), European (99.9th percentile of European ΔF = 0.422) or admixed-American ancestries (99.9th percentile of admixed-American ΔF = 0.281) (Figure 1). Considering each SD diagnosis separately, we observed high ΔF values in variants potentially associated with a large functional effect in GWAS-relevant genes and their interacting partners in AD, ND and OD (Supplementary Tables 4, 5 & 6, respectively). Table 1 reports the common variants with top ΔF that are also potentially associated with regulatory functions observed in each GWAS-relevant gene.
