Chunk #39 — OVERVIEW OF STATISTICAL METHODS — 2. Analysis of Incident Detection and/or Persistence of HPV — Frailty Models — Clearance / Persistence of HPV

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Marginal and mixed-effects models in the analysis of human papillomavirus natural history data.

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HPV persistence can be measured as the time to clearance of an HPV type following its initial detection, with clearance defined as the first subsequent negative result (or preferably two sequential negative results) for that HPV type(6,8). The WLW and frailty models described above can be used to assess time to clearance of HPV on a type-specific basis(6,8).