Marginal and mixed-effects models in the analysis of human papillomavirus natural history data.
paper
Cited
Public
- Authors
- Xue, Xiaonan; Gange, Stephen J; Zhong, Ye; Burk, Robert D; Minkoff, Howard; Massad, L Stewart; Watts, D Heather; Kuniholm, Mark H; Anastos, Kathryn; Levine, Alexandra M; Fazzari, Melissa; D'Souza, Gypsyamber; Plankey, Michael; Palefsky, Joel M; Strickler, Howard D
- Year
- 2010
- Journal
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- PMID
- 20056635
- DOI
- 10.1158/1055-9965.EPI-09-0546
- PMCID
- PMC2839537
Human papillomavirus (HPV) natural history has several characteristics that, at least from a statistical perspective, are not often encountered elsewhere in infectious disease and cancer research. There are, for example, multiple HPV types, and infection by each HPV type may be considered separate events. Although concurrent infections are common, the prevalence, incidence, and duration/persistence of each individual HPV can be separately measured. However, repeated measures involving the same subject tend to be correlated. The probability of detecting any given HPV type, for example, is greater among individuals who are currently positive for at least one other HPV type. Serial testing for HPV over time represents a second form of repeated measures. Statistical inferences that fail to take these correlations into account would be invalid. However, methods that do not use all the data would be inefficient. Marginal and mixed-effects models can address these issues but are not frequently used in HPV research. The current study provides an overview of these methods and then uses HPV data from a cohort of HIV-positive women to illustrate how they may be applied, and compare their results. The findings show the greater efficiency of these models compared with standard logistic regression and Cox models. Because mixed-effects models estimate subject-specific associations, they sometimes gave much higher effect estimates than marginal models, which estimate population-averaged associations. Overall, the results show that marginal and mixed-effects models are efficient for studying HPV natural history, but also highlight the importance of understanding how these models differ.
No figures extracted from this document.
1β20 of 57
Next β
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. | 2013 | 23089632 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Changes in Genital Human Papillomavirus (HPV) Prevalence During 12 Years of Girls-Only Bivalent HPV Vaccination: Results From a Biennial Repeated Cross-sectional Study. | Kusters JMA et al. | β | 2025 | β |
| Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners. | Moore A et al. | β | 2025 | β |
| Human Papillomavirus, Human Immunodeficiency Virus, and Oral Microbiota Interplay in Nigerian Youth (HOMINY): A Prospective Cohort Study Protocol. | Osagie E et al. | β | 2025 | β |
| Human papillomavirus incidence and transmission by vaccination status among heterosexual couples. | Moore A et al. | β | 2025 | β |
| Impact of HPV vaccination on the incidence and clearance of HPV infections in sexually active young women. | Kassam P et al. | β | 2025 | β |
| Detection and Clearance of Type-Specific and Phylogenetically Related Genital Human Papillomavirus Infections in Young Women in New Heterosexual Relationships. | Arthur AW et al. | β | 2024 | β |
| Epidemiology of genital human papillomavirus infections in sequential male sex partners of young females. | Arthur AW et al. | β | 2024 | β |
| Zipime-Weka-Schista study protocol: a longitudinal cohort study and economic evaluation of an integrated home-based approach for genital multipathogen screening in women, including female genital schistosomiasis, human papillomavirus, Trichomonas and HIV in Zambia. | Shanaube K et al. | β | 2024 | β |
| A novel human papillomavirus and host DNA methylation score and detection of cervical adenocarcinoma. | Gradissimo A et al. | β | 2023 | β |
| Concurrent Infection With Multiple Human Papillomavirus Types Among Unvaccinated and Vaccinated 17-Year-Old Norwegian Girls. | Laake I et al. | β | 2022 | β |
| Effects of Sex, Existing Antibodies, and HIV-1-Related and Other Baseline Factors on Antibody Responses to Quadrivalent HPV Vaccine in Persons With HIV. | Kang M et al. | β | 2022 | β |
| Evaluating the Jaccard Similarity Index as a Persistence Measure of Multiple Anal Human Papillomavirus Among Nigerian Men Who Have Sex With Men. | Nowak RG et al. | β | 2022 | β |
| Possible Reactivation of Latent Anal Human Papillomavirus Associated with Markers of Immune Dysfunction in Gay and Bisexual Men. | Poynten IM et al. | β | 2022 | β |
| Risk factors for placental human papillomavirus infection. | Niyibizi J et al. | β | 2022 | β |
| Risk Factors for Non-Human Papillomavirus (HPV) Type 16/18 Cervical Infections and Associated Lesions Among HPV DNA-Negative Women Vaccinated Against HPV-16/18 in the Costa Rica Vaccine Trial. | Sierra MS et al. | β | 2021 | β |
| Efficacy of the AS04-Adjuvanted HPV16/18 Vaccine: Pooled Analysis of the Costa Rica Vaccine and PATRICIA Randomized Controlled Trials. | Tota JE et al. | β | 2020 | β |
| Epidemiological evidence that common HPV types may be common because of their ability to evade immune surveillance: Results from the Women's Interagency HIV study. | Castle PE et al. | β | 2020 | β |
| Human Papillomavirus Seroprevalence and Seroconversion Among Men Living With HIV: Cohort Study in South Africa. | Chikandiwa A et al. | β | 2020 | β |
| Incidence and clearance of penile human papillomavirus infection among circumcised Kenyan men. | Backes DM et al. | β | 2020 | β |
| Transmission reduction and prevention with HPV vaccination (TRAP-HPV) study protocol: a randomised controlled trial of the efficacy of HPV vaccination in preventing transmission of HPV infection in heterosexual couples. | MacCosham A et al. | β | 2020 | β |
| Assessment of herd effects among women and heterosexual men after girls-only HPV16/18 vaccination in the Netherlands: A repeated cross-sectional study. | Woestenberg PJ et al. | β | 2019 | β |
| Incidence, Persistence, Clearance, and Correlates of Genital Human Papillomavirus Infection and Anogenital Warts in a Cohort of Men Living With Human Immunodeficiency Virus in South Africa. | Chikandiwa A et al. | β | 2019 | β |
| Prevalent, persistent anal HPV infection and squamous intraepithelial lesions: Findings from a cohort of men living with HIV in South Africa. | Chikandiwa A et al. | β | 2019 | β |
| Bivalent Vaccine Effectiveness Against Type-Specific HPV Positivity: Evidence for Cross-Protection Against Oncogenic Types Among Dutch STI Clinic Visitors. | Woestenberg PJ et al. | β | 2018 | β |
| Detection of Incident Anal High-Risk Human Papillomavirus DNA in Men Who Have Sex With Men: Incidence or Reactivation? | Twisk DE et al. | β | 2018 | β |
| Human Papillomavirus Serology Among Women Living With HIV: Type-Specific Seroprevalence, Seroconversion, and Risk of Cervical Reinfection. | Kelly H et al. | β | 2018 | β |
| Prevalence, incidence and correlates of low risk HPV infection and anogenital warts in a cohort of women living with HIV in Burkina Faso and South Africa. | Chikandiwa A et al. | β | 2018 | β |
| Racial differences in human papilloma virus types amongst United States women with HIV and cervical precancer. | Keller MJ et al. | β | 2018 | β |
| Analysis of Survival Data: Challenges and Algorithm-Based Model Selection. | Sarkar K et al. | β | 2017 | β |
| A statistical method for studying correlated rare events and their risk factors. | Xue X et al. | β | 2017 | β |
| Epidemiology of high-risk human papillomavirus and cervical lesions in African women living with HIV/AIDS: effect of anti-retroviral therapy. | Kelly HA et al. | β | 2017 | β |
| High lifetime probability of screen-detected cervical abnormalities. | Pankakoski M et al. | β | 2017 | β |
| The Natural History of Oral Human Papillomavirus in Young Costa Rican Women. | Beachler DC et al. | β | 2017 | β |
| Anal human papillomavirus in HIV-uninfected men who have sex with men: incidence and clearance rates, duration of infection, and risk factors. | DonΓ MG et al. | β | 2016 | β |
| Association of cervical precancer with human papillomavirus types other than 16 among HIV co-infected women. | Massad LS et al. | β | 2016 | β |
| Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: estimates and risk factors. | Geskus RB et al. | β | 2016 | β |
| Risk of Delayed Human Papillomavirus Vaccination in Inner-City Adolescent Women. | Schlecht NF et al. | β | 2016 | β |
| The Cervicovaginal Microbiota and Its Associations With Human Papillomavirus Detection in HIV-Infected and HIV-Uninfected Women. | Reimers LL et al. | β | 2016 | β |
| Vaginal high-risk human papillomavirus infection in a cross-sectional study among women of six different ethnicities in Amsterdam, the Netherlands: the HELIUS study. | Alberts CJ et al. | β | 2016 | β |
| Association of HIV Infection With Anal and Penile Low-Risk Human Papillomavirus Infections Among Men Who Have Sex With Men in Amsterdam: The HIV & HPV in MSM Study. | Welling CA et al. | β | 2015 | β |
| Cervical Precancer Risk in HIV-Infected Women Who Test Positive for Oncogenic Human Papillomavirus Despite a Normal Pap Test. | Keller MJ et al. | β | 2015 | β |
| Combination antiretroviral therapy reduces the detection risk of cervical human papilloma virus infection in women living with HIV. | Zeier MD et al. | β | 2015 | β |
| Evaluation of using composite HPV genotyping assay results to monitor human papillomavirus infection burden through simulation. | Lin CY | β | 2015 | β |
| Human Papillomavirus (HPV) Infections and the Importance of HPV Vaccination. | Wang CJ et al. | β | 2015 | β |
| Risk factors for acquisition and clearance of oral human papillomavirus infection among HIV-infected and HIV-uninfected adults. | Beachler DC et al. | β | 2015 | β |
| Anal, penile, and oral high-risk HPV infections and HPV seropositivity in HIV-positive and HIV-negative men who have sex with men. | van Rijn VM et al. | β | 2014 | β |
| Cervical human papillomavirus testing to triage borderline abnormal pap tests in HIV-coinfected women. | DΚΌSouza G et al. | β | 2014 | β |
| Dense genotyping of immune-related loci identifies variants associated with clearance of HPV among HIV-positive women in the HIV epidemiology research study (HERS). | Sudenga SL et al. | β | 2014 | β |
| Functional variants in CYP1A1 and GSTM1 are associated with clearance of cervical HPV infection. | Sudenga SL et al. | β | 2014 | β |
| Genital tract HIV RNA levels and their associations with human papillomavirus infection and risk of cervical precancer. | Ghartey J et al. | β | 2014 | β |
| HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM. | Mooij SH et al. | β | 2014 | β |
| Long-term cumulative detection of human papillomavirus among HIV seropositive women. | Massad LS et al. | β | 2014 | β |
| No evidence for a protective effect of naturally induced HPV antibodies on subsequent anogenital HPV infection in HIV-negative and HIV-infected MSM. | Mooij SH et al. | β | 2014 | β |
| Population- and type-specific clustering of multiple HPV types across diverse risk populations in the Netherlands. | Mollers M et al. | β | 2014 | β |
| Prevalence of HPV infection among clinically healthy Italian males and genotype concordance between stable sexual partners. | Lorenzon L et al. | β | 2014 | β |
| Sexual transmission of oral human papillomavirus infection among men. | Dahlstrom KR et al. | β | 2014 | β |
| Six-month incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men. | Mooij SH et al. | β | 2014 | β |
| Twelve-month incidence and clearance of oral HPV infection in HIV-negative and HIV-infected men who have sex with men: the H2M cohort study. | van Aar F et al. | β | 2014 | β |
| A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. | Wang JC et al. | β | 2013 | β |
| Anal and penile high-risk human papillomavirus prevalence in HIV-negative and HIV-infected MSM. | van Aar F et al. | β | 2013 | β |
| Key considerations and current perspectives of epidemiological studies on human papillomavirus persistence, the intermediate phenotype to cervical cancer. | Sudenga SL et al. | β | 2013 | β |
| Natural history of anal vs oral HPV infection in HIV-infected men and women. | Beachler DC et al. | β | 2013 | β |
| Patterns of human papillomavirus DNA and antibody positivity in young males and females, suggesting a site-specific natural course of infection. | Vriend HJ et al. | β | 2013 | β |
| Prevalence, incidence and persistence of genital HPV infections in a large cohort of sexually active young women in the Netherlands. | Mollers M et al. | β | 2013 | β |
| Retention among North American HIV-infected persons in clinical care, 2000-2008. | Rebeiro P et al. | β | 2013 | β |
| Sexual behaviour and less frequent bathing are associated with higher human papillomavirus incidence in a cohort study of uncircumcised Kenyan men. | Backes DM et al. | β | 2013 | β |
| Variants in interleukin family of cytokines genes influence clearance of high risk HPV in HIV-1 coinfected African-American adolescents. | Sudenga SL et al. | β | 2013 | β |
| A proof-of-concept randomized controlled study of gabapentin: effects on cannabis use, withdrawal and executive function deficits in cannabis-dependent adults. | Mason BJ et al. | β | 2012 | β |
| Cervical, anal and oral HPV in an adolescent inner-city health clinic providing free vaccinations. | Schlecht NF et al. | β | 2012 | β |
| Cervicovaginal human papillomavirus (HPV)-infection before and after hysterectomy: evidence of different tissue tropism for oncogenic and nononcogenic HPV types in a cohort of HIV-positive and HIV-negative women. | D'Souza G et al. | β | 2012 | β |
| Effect of human immunodeficiency virus infection on the prevalence and incidence of vaginal intraepithelial neoplasia. | Massad LS et al. | β | 2012 | β |
| Risk factors for oral HPV infection among a high prevalence population of HIV-positive and at-risk HIV-negative adults. | Beachler DC et al. | β | 2012 | β |
| Transitional probability-based model for HPV clearance in HIV-1-positive adolescent females. | Kravchenko J et al. | β | 2012 | β |
| Clustering of human papillomavirus (HPV) types in the male genital tract: the HPV in men (HIM) study. | Vaccarella S et al. | β | 2011 | β |
| Clustering of multiple human papillomavirus infections in women from a population-based study in Guanacaste, Costa Rica. | Vaccarella S et al. | β | 2011 | β |
| Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal study. | Low AJ et al. | β | 2011 | β |
| Genital warts and vulvar intraepithelial neoplasia: natural history and effects of treatment and human immunodeficiency virus infection. | Massad LS et al. | β | 2011 | β |
| Increases in human papillomavirus detection during early HIV infection among women in Zimbabwe. | Nowak RG et al. | β | 2011 | β |
| Multiple human papillomavirus infections: the exception or the rule? | Plummer M et al. | β | 2011 | β |
| A modeling framework for the analysis of HPV incidence and persistence: a semi-parametric approach for clustered binary longitudinal data analysis. | Kong X et al. | β | 2010 | β |
| Influence of adherent and effective antiretroviral therapy use on human papillomavirus infection and squamous intraepithelial lesions in human immunodeficiency virus-positive women. | Minkoff H et al. | β | 2010 | β |
| Marijuana use is not associated with cervical human papillomavirus natural history or cervical neoplasia in HIV-seropositive or HIV-seronegative women. | D'Souza G et al. | β | 2010 | β |