Data were obtained from the Women’s Interagency HIV Study (WIHS) cohort. Details of this cohort have been previously reported(6,7,8). Briefly, between October, 1994 and November, 1995, 2,058 HIV-seropositive and 568 HIV-seronegative women older than 13 years were enrolled in the WIHS from similar clinical and outreach sources in Brooklyn/Manhattan/Bronx, NY; Chicago, IL; Los Angeles and San Francisco, CA; and Washington, DC. In 2002, an additional 738 HIV-seropositive and 406 HIV-seronegative women were similarly enrolled. On a semiannual basis in this ongoing cohort subjects undergo a structured interview and a physical examination that includes a gynecologic examination. Following a Pap smear, a cervicovaginal lavage (CVL) is collected for HPV DNA testing, as are blood samples. At the time of this analysis, there was a median follow-up of 14 visits among all subjects, with 9,475 persons-years of observation among HIV-positive women, and 2,708 person-years among HIV-negative women.
