Chunk #14 — OVERVIEW OF STATISTICAL METHODS — 1. Analysis of HPV Prevalence — Generalization Estimating Equation (GEE) Models — Multiple HPV Types

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Marginal and mixed-effects models in the analysis of human papillomavirus natural history data.

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To illustrate how GEE models can be used to model multiple types of HPV measured across multiple visits, let Yijk represent the infection of HPV type k for the ith person at jth semiannual visit. To assess an overall effect estimate across oncogenic HPV types, a type-specific baseline prevalence is assumed for each type of infection but a common odds ratio is assumed across the types, the infection rate of Yijk,Pijk , is modeled by (1.3)logitPijk=β0+θk+βZij+γWij.