Fasting serum triglycerides were associated with variants in the intron and 3′UTRs within the APOA5-ZNF259 region. APOA5 is an important determinant of circulating triglyceride levels [36]. SNPs detected in our GWAS have been associated with triglycerides in other populations [37]. In the Kosrae population, triglyceride levels were associated with seven SNPs near APOC3/A5 [38]. Variants in the APOA5-ZNF259 region (including rs3741298) were associated with HDL-C and ApoA-1 response to therapy with statins and fenofibric acid in patients with dyslipidemia [39].
