The DV genes were highly enriched (P < 10−42) in a single coexpression module (greenyellow). The module was of moderate size (227 members) and, not surprisingly, was significantly enriched in annotations associated with receptor signaling and neuronal membrane-related genes. Using our consensus module approach for selection line data (Iancu et al. 2013a, 2013b), it was observed that essentially all of the hub nodes in the greenyellow module were affected by selection. Using the EnrichR tool (Chen et al. 2013; Kuleshov et al. 2016), these hub nodes were not detected as significantly enriched in TF- or mi-RNA-binding sites. However, the protein–protein interaction hub protein tool showed that a significant number of the greenyellow hub nodes were functionally downstream from Fyn kinase (corrected P < 7 × 10−7). This cluster of hub nodes included Cdkl5, Dcc, Pde4d, Gpr63, Cbl, Dock1 and Add2. Fyn has been implicated in the regulation of a variety of ethanol phenotypes; Fyn knockout (KO) mice have been reported to show decreased or no difference in preference consumption and mice overexpressing Fyn have been reported to have decreased preference
