Fyn has been implicated in the regulation of a variety of ethanol phenotypes; Fyn knockout (KO) mice have been reported to show decreased or no difference in preference consumption and mice overexpressing Fyn have been reported to have decreased preference consumption (Boehm et al. 2003; Chen & Charness 2008; Farris & Miles 2013; Lee & Messing 2008; Yaka et al. 2003). Fyn is a member of the greenyellow module but was not significantly affected by selection. It also should be noted that among the Fyn-related cluster of hub nodes is Cdkl5, which has been associated with alcoholism (Liu et al. 2006; Sokolov et al. 2003).
