QIMR Twins Replication Cohort: Data for Australian subjects were obtained from adult participants in twin and family studies conducted by the Queensland Institute of Medical Research [15], [16], [35]. BMI was calculated from clinically measured height and weight supplemented with self-report for those participants where clinical measurements were not available. CRP and LDL-C (calculated from the Friedewald equation) measurements were performed using Roche methods on Hitachi 917 or Modular P analysers. The data used here represent 4781, 2767 and 2630 individuals who had genome-wide SNP information and information on BMI, CRP and LDLc respectively. A maximum of one individual per family was used in these analyses, yielding a set of unrelated individuals who had not contributed any data to the previous BMI, CRP or LDLc meta-analyses.
