A number of recent studies have associated rs1076560 with brain function and cognitive phenotypes in healthy controls. rs1076560 is associated with neuronal connectivity in the amygdala, dorsolateral prefrontal cortex and striatal regions (Blasi et al., 2009, Sambataro et al., 2011), and differences in resting posterior minus frontal electroencephalographic (EEG) slow oscillations (Koehler et al., 2011). Brain activity in the left basal ganglia, thalamus, supplementary motor area, and primary motor cortex was also found to be associated with rs1076560 (Blasi et al.). These differences in brain function have been found to correlate with alterations in working memory, reaction time and impairments in negative decision making (Bertolino et al., 2009, Bertolino et al., 2010, Fazio et al., 2011, Frank & Hutchison, 2009).
