As rs1076560 is linked to differences in brain function, it is perhaps not surprising that the SNP is associated with various psychiatric disorders. The minor allele of rs1076560 has been associated with working memory and schizophrenia phenotypes (Bertolino et al., 2009, Blasi et al., 2011). rs1076560 has been associated with schizophrenia in two independent cohorts of Chinese patients (Zheng et al., 2012) and an interaction between rs1076560 and a SNP in AKT1 is associated with the response to olanzapine in schizophrenic patients (Blasi et al., 2011). rs1076560 is also relevant for addiction to alcohol, as its minor allele is found at a greater frequency in Japanese alcoholic patients compared to healthy controls (P=0.03, OR=1.3) (Sasabe et al., 2007). Furthermore, D2 receptor availability is associated with rs1076560 in alcoholic patients (Lucht et al., 2010).
