Despite the body of research suggesting that the pharmacological effects of alcohol vary by limb of BAC, human laboratory studies have largely failed to consider limb of intoxication when examining the subjective responses to alcohol. Based on the known pharmacokinetics of alcohol and methods of calculating circulating alcohol (Brick, 2006) the limb of intoxication can often be broadly inferred in most alcohol administration studies via the time elapsed between alcohol intake and assessment, but there is nonetheless substantial ambiguity in the literature. Considering limb of intoxication may also be critically important in evaluating the subjective effects of alcohol and medications, such as naltrexone, that are thought to alter the subjective responses to alcohol. This is especially important given that the effects of alcohol clearly vary by limb of the BAC, with well-documented limb-dependent alcohol effects on expectancies (Dunn & Earleywine, 2001), memory (Soderlund et al. 2005), cognitive performance (Pihl et al., 2003), and the unpleasant subjective effects of alcohol (Evans & Levin, 2004). Specifically, light drinkers3 are more likely than heavy drinkers to activate negative and sedating alcohol expectancies associated
