The top replication SNP from each of the follow-up regions is presented in Table 2. Results for all tested SNPs and indels are presented in S3 Table. An intronic SNP, rs4878712, in the FERM And PDZ Domain Containing 1 (FRMPD1) gene on chromosome 9 replicated at P = 1.38x10-4, which surpassed our threshold for multiple testing correction. Its meta-analysis P-value across UHS and WIHS was P = 4.47x10-7 with the G allele consistently showing a protective effect for HIV acquisition. The G allele had a lower frequency in cases vs. controls for both ancestry groups in UHS and WIHS: 0.27 vs. 0.33 in UHS AAs, 0.54 vs. 0.56 in UHS EAs, 0.30 vs. 0.35 in WIHS AAs, and 0.52 vs. 0.57 in WIHS EAs. The rs4878712 SNP is located approximately 600kb away from the SNP with the smallest meta-analysis P-value from the discovery analysis of the UHS, rs1329568 (S6H and S7H Figs.). D’ values between rs4878712 and rs1329568 are high in EUR (1.0), but of modest statistical significance, and limited in AFR (0.22) (S8A and S9A Figs.). Their r2 values
