In addition to the top 8 gene regions, we used the UHS meta-analysis results to look-up 24 candidate SNPs that were previously implicated for their suggestive association with HIV-1 acquisition as reviewed by An and Winkler [38] or McLaren et al. [6–9,11,12](S2 Table). None of these previously suggested candidate SNPs had meta-analysis P<0.05 in this study.