Bayesian effect strength estimation confirmed that the effect of 5-HTTLPR on depression was relevant in the presence of RLEs. Namely, ss compared to ll genotype carriers have increased risk for lifetime depression and have higher BSI depression scores in subjects with medium (DEP: ORBayesian = 1.24–1.77; BSI-DEP: ORBayesian = 1.29–1.39) or high (DEP: ORBayesian = 1.85–2.4; BSI-DEP: ORBayesian = 1.67–2.4) RLE (Fig. 1B, 1D) but it has non-relevant effect (ORBayesian≈1) in subjects with low RLE. The relatively flat posterior distribution curves in case of high RLE indicate several possible Bayesian Odds Ratio values with moderate or low certainty. Bimodal distribution for medium RLE subjects suggests that one group of models supports one, and another group of models supports another odds ratio.
