There were no significant interaction effects of childhood adversity and 5-HTTLPR genotypes on lifetime depression or on BSI depression scores (Table 2). However, 5-HTTLPRxRLE interaction on BSI depression scores was significant in those who experienced medium or high childhood adversity. This remained significant at trend level in the younger age group but did not approach significance in the older group. In contrast, there was no 5-HTTLPRxRLE interaction among subjects with either no childhood adversity or age above 30 (Table D in S1 File).
