In a Kaplan–Meier analysis of IS, the top and bottom 10% of the metaGRS showed substantial differences in cumulative incidence of IS (Supplementary Fig. 4; log-rank test between the top decile and the 45–55% decile: P = 3 × 10−6); these results were consistent with a Cox proportional hazards model of the metaGRS assessing the HRs for the top 10% decile vs the middle 45–55% decile (Supplementary Fig. 5). The top 0.25% of the population were at a threefold increased risk of IS vs. the middle decile (45–55%), with HR = 3.0 (95% CI 1.96–4.59) (Fig. 3).
