A recent study (Tantisira et al. 2008) found an association with inhaled corticosteroid response in asthma for four SNPs that tag the H2 haplotype in samples from populations in which a similar association had been previously attributed (Tantisira et al. 2004) to rs1876828, a CRHR1 SNP. Similarly, the minor allele of rs1876831, the CRHR1 polymorphism for which a significant G × E interaction associated with risk for alcohol consumption was previously reported (Blomeyer et al. 2008), is also contained within the H2 haplotype. Research on this region has also not yet been integrated into the psychiatric literature.
