The current report examines whether a similar G × E interaction is observed involving the H2 haplotype and history of CSA that is protective against alcohol consumption and DSM-IV alcohol dependence in the Australian sample of the Nicotine Addiction Genetics (NAG) project (Saccone et al. 2007; Agrawal et al. 2008). Our large sample, drawn from a heavy-drinking population, enriched for regular smokers [rates of regular smoking in clinical samples of alcoholics approach 90% (Hurt et al. 1996)], and having largely survived the period of greatest risk for the onset of alcohol dependence, is particularly well-suited for this investigation.
