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Chunk #19 — 2. Methods — 2.6. DMN Seed Regions and FC Calculations

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Random Forest Classification of Alcohol Use Disorder Using fMRI Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures.
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al. [77] who have reportedly derived the seeds from the work of Buckner et al. [78]. These seed regions included six anatomical locations involving both hemispheres: the posterior cingulate cortex (PCC), anterior cingulate cortex (ACC), inferior parietal cortex (IPL), PFC, LTC, and the parahippocampal gyrus (PHG) (Table 2 and Figure 1). Each seed region contained the voxels within a 10 mm radius from the peak/centroid point of the anatomical locations referenced using the eLORETA software [79]. The ROI-to-ROI connectivity [80], the most commonly used method to derive FC across brain regions [81], was computed using Pearson correlation coefficients between all unique pairs (N = 66) of BOLD time series data of the DMN seed regions listed in Table 2. The resulting correlation coefficients were Fisher Z-transformed for further statistical analyses.