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Chunk #18 — 2. Methods — 2.6. DMN Seed Regions and FC Calculations

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Random Forest Classification of Alcohol Use Disorder Using fMRI Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures.
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Based on the empirical evidence from extensive rs-FC fMRI literature, the recent conceptualization of the default mode network by Andrews-Hanna et al. [75] has included voxels spanning six anatomical regions: (i) the medial prefrontal cortex (mPFC; dmPFC, rostral ACC, and parts of the anterior and ventral mPFC), (ii) the lateral frontal cortex (superior frontal cortex and inferior frontal gyrus), (iii) the medial parietal cortex (PCC and retrosplenial cortex), (iv) the medial temporal lobe (hippocampus and PHF), (v) the lateral parietal cortex (spanning angular gyrus and posterior supramarginal gyrus), and (iv) the lateral temporal cortex (LTC) (extending anteriorly to the temporal poles). The seed regions of the DMN for the current study were adapted from this theoretical review as well as from the LORETA (Low Resolution Electromagnetic Tomography) studies on EEG current sources by Imperatori et al. [76] and Thatcher et al. [77] who have reportedly derived the seeds from the work of Buckner et al. [78]. These seed regions included six anatomical locations involving both hemispheres: the posterior cingulate cortex (PCC), anterior cingulate cortex (ACC), inferior parietal cortex (IPL), PFC,