Building on these results, sensation seeking demonstrated genetic correlations with resting‐state functional connectivity phenotypes. Specifically, sensation seeking was associated with increased somatomotor intra‐connectivity and decreased connectivity between the somatomotor and cerebellar networks, which are increasingly emphasised in neurobiological models of addiction. 61 Sensation seeking was also consistently negatively correlated with functional connectivity between somatomotor/dorsal attention networks and the putamen, highlighting shared genetic influences between sensation seeking and reduced co‐activity along parieto‐limbic pathways. 62 In aggregate, the sensation seeking GWAS and follow‐up analyses provide evidence of genetic influences implicating plausible neurobiological mechanisms involved in the aetiology of sensation seeking (e.g., neuronal development, cell signalling, and dopaminergic/reward pathways) that extend beyond the hypothesised subcortical regions associated with ‘bottom‐up’ processes.
