Here I review recent studies that indicate that coupling between theta and gamma oscillations plays an important role in functions of the entorhinal-hippocampal network. I will first describe recent studies suggesting that theta-gamma coupling enhances memory processing. I will then discuss recent results that shed light on the question of how theta-gamma coupling arises. Finally, I will present possible ways in which theta-gamma coupling may promote effective memory processing in the entorhinal-hippocampal network.