The distribution of genotypes and alleles of the Val158Met polymorphism by gender failed to detect a difference between controls and subjects with anxiety and depression using the cut-off score ≥ 8 for HADS-A and HADS-D. When utilizing the alternative cut-off score ≥ 11, the Met/Met genotype and Met allele were less common among men with depression compared to the controls (genotype: 18.3% versus 33.9%, p = 0.017; allele: 46.5% versus 58.1%, p = 0.006) (Table 2). In the multivariate analysis, adjusting for age and heart diseases, HADS-D ≥ 11 was less likely among men with the Met/Met genotype than among men with the Val/Val genotype (OR = 0.37, 95% CI = 0.18–0.76). For women, this tendency was less clear (OR = 0.89, 95% CI 0.48–1.63). However, for both genders combined, depression was less common for the Met/Met genotype (OR = 0.60, 95% CI = 0.38–0.95).
