We went on to examine enrichment of residual (i.e., unique) variance for the individual disorders in the correlated factors model and the residuals of the psychiatric factors in the hierarchical model (Supplementary Table 10). Results for the individual disorders revealed 17 significant residual enrichment estimates at a Bonferroni-corrected threshold. This included 13 significant estimates for various disorders within evolutionarily conserved annotations (e.g., conserved primate), along with significant enrichment unique to MDD for coding regions and the PI × excitatory dentate gyrus neurons annotation.
