PI results revealed that these annotations were particularly enriched for the Psychotic disorders factor, with 5 out of the 10 most significantly enriched gene sets falling in this category (Fig. 5). The most enriched annotations for the Neurodevelopmental and Internalizing disorders factors were fetal female brain DNase and fetal male brain H3K4me1, respectively. For specific tissues, brain regions were generally enriched, as was also observed for other complex traits35, but were most enriched for the Psychotic disorders factor. Genetic sharing across disorders, as estimated by a higher order p-factor, was enriched in conserved annotations, and enrichment increased from low to high MAF alleles (Supplementary Figs. 19-24).
