We fit Stratified Genomic SEM models to examine whether the degree of risk sharing and differentiation is enriched across disorders. In total, enrichment analyses were based on 168 binary annotations. This included 29 annotations created to examine the interaction between expression patterns for protein-truncating variant (PTV)–intolerant (PI) genes (obtained from the Genome Aggregation Database; gnomAD33) and human brain cells in the hippocampus and prefrontal cortex (obtained from GTEx34). Using a Bonferroni correction for 168 tests, we identify 40 annotations significantly enriched for the Psychotic disorders factor, one annotation (conserved primate) for the Neurodevelopmental disorders factor, four annotations for the Internalizing disorders factor, and 38 annotations for the p-factor (Supplementary Table 10 and Supplementary Figs. 12-18).
