Despite these limitations, our study is one of the largest schizoph0renia neuroimaging studies conducted to date, and provides the first longitudinal evidence that the normative neurodevelopmental correlates of genetic variants impacting dopamine signaling are disrupted in people with schizophrenia as well as their unaffected relatives. Our findings further suggest that while some of these disruptions reflect primary genetic or environmental risks shared between probands and siblings, others only arise in the context of active disease.
