r=0.96 for FEV1). As expected, there was some attenuation in P values for many of the SNPs in our implicated loci given the substantial power loss due to both reduced sample size and the truncation of the FEV1/FVC and FEV1 distributions, but there was substantial overlap in the top-ranking SNPs between the two meta-analyses (results not shown). The P values for some top-ranking SNPs became smaller, including several ADAM19, FAM13A, and HTR4 SNPs associated with FEV1/FVC. Of note, 12 SNPs in HTR4, a locus with one SNP rs11168048 showing borderline genome-wide significance in the original meta-analysis, gave genome-wide significance in the subset of individuals without asthma or COPD (P=6.93×10−9 for rs11168048).
